ANTIPYRETICS. III. ACETYLSALICYLIC ACID AND HEAT REGULATION IN FEVER CASES

Fever: Its Pathology and Treatment by Antipyretics

Fever: beneficial and detrimental effects of antipyretics.

Although various forms of therapy have been used, since antiquity, to lower the temperature of febrile patients, it is still not known whether the benefits of antipyretic therapy outweigh its risks. Justifications for the use of antipyretic drugs, and the evidence pertaining to these rationales, are examined. Antipyretic therapy in sepsis, and adverse effects of antipyretic medications, are als...

Antipyretics: mechanisms of action and clinical use in fever suppression.

Fever is a complex physiologic response triggered by infectious or aseptic stimuli. Elevations in body temperature occur when concentrations of prostaglandin E(2) (PGE(2)) increase within certain areas of the brain. These elevations alter the firing rate of neurons that control thermoregulation in the hypothalamus. Although fever benefits the nonspecific immune response to invading microorganis...

Kinetics of oxidation of acetylsalicylic acid ( Aspirin ) by manganese ( III ) in pyrophosphate medium

Manganese( III) has been stabili zed in weakly acidic med ium by means of pyrophosphate and the nature of the complex elucidated spectrophotometricall y. Stoichiometry of manganese( JJJ) oxidation of aspirin (acetylsalicylic acid) in pyrophosphate has been establi shed in the pH range 2.3-3.5 by iodometric and spectrophotometric methods. The reac ti on foll ows first order kinetics in [Mn(IIl)j...

Acetylsalicylic acid--induced hemolysis and its mechanism.

Acetylsalicylic acid (ASA) is known to cause severe hemolytic anemia in some glucose-6-phosphate-dehydrogenase-deficient (G-6-PD-deficient) individuals. To study its mechanism, erythrocytes from an ASA-sensitive patient were transfused into a normal compatible recipient. The administration of 2,5-dihydroxybenzoic (gentisic) acid, a known ASA metabolite with redox properties, to the recipient re...